TS. Đặng Thế Hưng

Chức danh và vị trí công tác: 

Phó giám đốc phụ trách Trung Tâm Xét nghiệm

Lĩnh vực chuyên môn chuyên sâu: 

Dược học (Hóa Dược)

• Dang, H.T.; Chorell, E.; Uvell, H.; Pinkner, J. S.; Hultgren, S. J.; Almqvist, F. Syntheses and biological evaluation of 2-amino-3-acyl-tetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activity. Org. Biomol. Chem. 2014, 12, 1942-1956.
• Sellstedt, M.; Dang, H.T, Prasad, G. K.; Sauer, U.; Almqvist, F. Four-component assembly of natural product-like ring-fused isoquinuclidines. Eur. J. Org. Chem. 2013, 33, 7476-7479. 
• Kang, G. J.; Dang, H.T.; Han, S. C.; Kang, N. J.; Koo, D. H.; Koh, Y. S.; Hyun, J. W.; Kang, H. K.; Jung, J. H.; Yoo, E. S. Methyl 5-​chloro-​4,​5-​didehydrojasmonate (J7) inhibits macrophage-​derived chemokine production via down-​regulation of the signal transducers and activators of transcription 1 pathway in HaCaT human keratinocytes. Chem. Pharm. Bull. 2013, 61, 1002-1008. 
• Dang, H. T.; Xiao, B.; Lee, Y. M.; Hong, J.; Lee, C. O.; Choi, J. S.; Jung, J. H. Synthesis of fellutamide C and its diastereomer. Bull. Korean Chem. Soc. 2012, 33, 2777-2780.
• Dang, H. T.; Lee, Y. M.; Kang, G. J.; Yoo, E. S.; Hong, J.; Lee, S. M.; Lee, S. K.; Pyee, Y.; Chung, H. J.; Moon, H. R.; Kim, H. S.; Jung, J. H. In vitro stability and in vivo anti-inflammatory efficacy of synthetic jasmonates. Bioorg. Med. Chem. 2012, 20, 4109-4116.
• Eun, L. K.; Li, J. L.; Dang, H. T.; Hong, J.; Lee, C. O.; Kim, D. K.; Yoon, W. D.; Kim, E.; Liu, Y.; Jung, J. H. Cytotoxic cytochalasins from the endozoic fungus Phoma sp. of the giant jellyfish Nemopilema nomurai. Bioorg. Med. Chem. Lett. 2012, 22, 3126-3129.
• Lee, Y. M.; Dang, H. T.; Li, J. L.; Zhang, P.; Hong, J.; Lee, C. O.; Jung, J. H. A cytotoxic fellutamide analogue from the sponge-derived fungus Aspergillus versicolor. Bull. Korean Chem. Soc. 2011, 321, 3817-3820.
• Dang, H. T.; Kang, G. J.; Yoo, E. S.; Lee, Y. M.; Hong, J.; Kim, D. K.; Jung, J. H. Evaluation of endogenous fatty acid amides and their synthetic analogues as potential anti-inflammatory leads. Bioorg. Med. Chem. 2011, 19, 1520-1527.
• Dang, H. T.; Lee, H. J.; Yoo, E. S.; Hong, J.; Choi, J. S.; Jung, J. H. The occurrence of 15-keto-prostaglandins in a plant-the red alga Gracilaria verrucosa. Arch. Pharm Res. 2010, 33, 1325-1329.
• Lee, Y. M.; Dang, H. T.; Hong, J.; Lee, C. O.; Bae, K. S.; Jung, J. H. A cytotoxic lipopeptide from a sponge-derived fungus Aspergillus versicolor. Bull. Korean Chem. Soc. 2010, 31, 205-208.
• Bao, B.; Dang, H. T.; Zhang, P.; Hong, J.; Lee, C. O.; Cho, H. Y.; Jung, J. H. Bicyclic a,w-dicarboxylic acid derivatives from a colonial tunicate of the family polyclinidae. Bioorg. Med. Chem. Lett. 2009, 19, 6205-6208.
• Lee, H. J.; Dang, H. T.; Kang, G. J.; Yang, E. J.; Park, S. S.; Yoon, W. J.; Jung, J. H.; Kang, H. K.; Yoo, E. S. Two enone fatty acids isolated from Gracilaria verrucosa suppress the production of inflammatory mediators by down-regulating NFKB and STAT1 activity in LPS-stimulated RAW 264.7 cells. Arch. Pharm Res. 2009, 32, 453-462. (Selected as the best research paper in the month of APR).
• Zhang, P.; Bao, B.; Dang, H. T.; Yoo, E. S.; Hong, J.; Jung, J. H. Anti-inflammatory sesquiterpenoids from a sponge-derived fungus Acremonium sp. J. Nat. Prod. 2009, 72, 270-275.
• Shinde, P. B.; Dang, H. T.; Huayue, L.; Hong, J.; Sook, S.; Jung, J. H. Chemical investigation of the sea cucumber Stichopus japonicus. Nat. Prod. Sci. 2008, 14, 12-15.
• Mohamed, E.; Shinde, P. B.; Dang, H. T.; Hong, J.; Bae, K. S.; Jung, J. H. Furan metabolites from the sponge-derived yeast Pichia membranaefaciens. J. Nat. Prod. 2008, 71, 869-872.
• Shinde, P. B.; Lee, Y. M.; Dang, H. T.; Hong, J.; Lee, C. O.; Jung, J. H. Cytotoxic bromotyrosine derivatives from a two-sponge association of Jaspis sp. and Poecillastra sp. Bioorg. Med. Chem. Lett. 2008, 18, 6414-6418.
• Miao, C.; Du, J.; Dang, H. T.; Jeong, I. H.; You, S.; Jung, J. H.; Kim, D. K. Apoptotic activity of fatty acid derivatives might correlate with their inhibition of DNA replication. Int. J.Oncol. 2008, 33, 1291-1298.
• Dang, H. T.; Lee, H. J.; Yoo, E. S.; Hong, J.; Bao, B.; Choi, J. S.; Jung, J. H. New jasmonate analogues as potential anti-inflammatory agents. Bioorg. Med. Chem. 2008, 16, 10228-10235.
• Dang, H. T.; Lee, H. J.; Yoo, E. S.; Shinde, P. B.; Lee, Y. M.; Hong, J.; Kim, D. K.; Jung, J. H. Anti-inflammatory constituents of the red alga Gracilaria verrucosa and their synthetic analogues. J. Nat. Prod. 2008, 71, 232-240.
• Jung, S. H.; Cho, S. H.; Dang, H. T.; Lee, J. H.; Ju, J. H.; Kim, M. K.; Lee, S. H.; Ryu, J. C.; Kim, Y. S. Structural requirement of isoflavonones for the inhibitory activity of interleukin-5. Eur. J. Med. 2003, 38, 537-545.

Patents: 

• New cannabinoid derivatives capable of inhibiting the over-expression of inflammatory mediators and medical use thereof. Jung, J. H.; Dang, H.T.; Yoo, E. S.; Kang, H. J.; Hong, J.; Chung, H. Y. KR20110088991.
• New jasmonate derivatives capable of controlling the over-expression of inflammatory mediators and medical use thereof. Jung, J. H.; Yoo, E. S.; Dang, H.T.; Kim, D. K. KR20100057343.
• Therapeutic agents containing compounds which suppress the over-expression of inflammatory mediators for treating inflammatory diseases. Jung, J. H.; Yoo, E. S.; Dang, H.T.; Kang, H. J. KR20090128229.
• Pharmaceutical composition containing enone fatty acid compounds for preventing and treating cancer. Jung, J. H.; Kim, D. K.; Yoo, E. S.; Dang, H.T.; Kang, H. J. KR20090128223.